Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It is used to treat moderate pain in adults and children of age 14 or above. Further, it is also used in the treatment of menstrual pain.
It is an anthranilic acid with anti-inflammatory, antipyretic and analgesic properties. It prevents the activity of the enzymes cyclo-oxygenase I and II that leads to decreased production of precursors of prostaglandins and thromboxanes. The decreased synthesis of prostaglandin by prostaglandin synthase is the reason for the therapeutic effects of Mefenamic acid. This acid also decreases the formation of thromboxane A2 synthesis, by thromboxane synthase and thus inhibits aggregation of the platelet.
Chemical Structure of Mefenamic Acid
The chemical name of mefenamic acid is 2-[(2, 3-dimethyl phenyl) amino] benzoic acid. In this anthranilic acid, one of the hydrogens bonded to nitrogen is replaced by a 2, 3-dimethylphenyl group.
Properties of Mefenamic Acid
How to take Mefenamic Acid?
Mefenamic acid is available in the form of tablets that are taken orally. It is usually consumed with food for up to 1 week. However, its intake depends on the medical condition and treatment reaction. One may take the lowest possible effective dosage for the minimum required duration to reduce the chances of stomach bleeding and other side effects. Further, don't increase the dosage, take it more often and for a longer duration instead, but not more than 7 days at a time.
The intake of Mefenamic acid can increase the chances of stroke or heart attack. It should not be taken just before or after heart bypass surgery. Further, it can also lead to stomach or intestinal bleeding that can be life-threatening.
So, you should not use Mefenamic acid if you are allergic to it or have any of the following medical conditions:
Further, pregnant women should consult their doctors before taking it and it should not be used for longer than 7 days.
Mefenamic acid side effects
Stop taking Mefenamic acid and seek medical help if you experience any of the following side effects:
Difference between Mefenamic acid and Paracetamol